In the last league I had a very effective but risky tactic of getting the ball to my human blitzer (with Block, Dodge, Stand Firm and Guard) as quick as possible and running him through the opponents line towards their end zone. He would be blitzed by many many people but Block, Dodge and Stand Firm along with very lucky rolls made him very difficult to knock over. Then, he would dodge out of the enemy's path to score a touchdown. When I didn't have the ball, I would kick it somewhere near his position on the feild and when the opposing catcher or whatever picked it up I would run the blitzer through the line and take the ball from him and score a touchdown. I usually got 3 touchdowns per game.
I'm starting up a new mini-league now, I've got 5 players with a few more looking into playing which should be fun.